Compartmentalize the system to have "safe" areas where trust boundaries can be unambiguously drawn. Do not allow sensitive data to go outside of the trust boundary and always be careful when interfacing with a compartment outside of the safe area.
Ensure that appropriate compartmentalization is built into the system design, and the compartmentalization allows for and reinforces privilege separation functionality. Architects and designers should rely on the principle of least privilege to decide the appropriate time to use privileges and the time to drop privileges.
Always check to see if you have successfully accessed a resource or system functionality, and use proper error handling if it is unsuccessful. Do this even when you are operating in a highly privileged mode, because errors or environmental conditions might still cause a failure. For example, environments with highly granular permissions/privilege models, such as Windows or Linux capabilities, can cause unexpected failures.